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Heel bone reconstruction (porous implant and bone allograft plasty), osteosynthesis using Ilizarov's external fixator
Complete gastric erosion of a Gastric Banding
This is the case of a 46-year-ald woman who had a gastric banding procedure 1,5 years before coming with symptoms of epigastric pain and vomiting. Upper GI endoscopy revealed the erosion of the band into the stomach.
This video shows the transgastric route to take out the band. Surgery may be difficult and a further bariatric procedure extremely hazardous.
Sleeve Gastrectomy Surgery
This is a brief video of the weight loss operation called sleeve gastrectomy. The stomach is freed on its greater curve using the Harmonic Scalpel (ultrasonic energy source), following which the stomach is transected along its length with the endoscopic stapler. The staple-line is reinforced with Seamguard, a buttress material that helps make the stapler line bloodless.
The whole procedure is laparoscopic.
Axillary Endoscopic Thyroidectomy
A small movie showing endoscopic thyroid surgery. This is specially suited for women and people who wish to avoid neck scars. The indication is restricted to tumors or cysts of up to 6 cm size. There are other approaches to endoscopic thyroidectomy.
laparoscopic ureterolysis with intraperitonealization of ureter in patients with idiopathic retroperitoneal fibreosis (IRPF)
ENDOSCOPIC THERAPY OF GERD USING ESOPHYX
Gastroesophageal reflux disease (GERD) can take place with or without hiatal hernia and can result in chronic irritation of the esophagus (chronic esophagitis) or Barrett esophagus with possible cancer. Till now the only way of fixing the problem was surgically with Nissen's fundoplication Toupet or Dor techniques. Now there is an endoscopic and less invasive technique with similar results and without the cuts that is called Esophyx TIF II with more than 4000 successful cases worldwide.
Gleevecs mechanism of Action
The animation begins by introducing the Philadelphia Chromosome, the result of a reciprocal translocation between chromosomes 9 and 22. More specifically the breakpoint cluster region (BCR) of chromosome 22 is fused with part of the Abelson (ABL) gene on chromosome 9. The resulting BCR-ABL genetic domain now located within chromosome 22 and codes for a mutant tyrosine kinase also known as BCR-ABL. Under normal circumstances tyrosine kinase proteins respond to external cellular messaging proteins, and ultimately initiate a series of reactions that culminate in cellular replication. Conversely, BCR-ABL is constitutively active, meaning it does not require activation by the aforementioned cellular messaging proteins in order to stimulate cellular replication. This results in acceleration of cell division, an inhibition of DNA repair, overall genomic instability, and the fatal blast crisis characteristic of chronic myelogenous leukemia. The animation progresses to introduce Gleevec (imatinib), the first in a class of drugs that specifically target and competively inhibit the ATP binding site on BCR-ABL tyrosine kinase. This prevents the ABL domain from phosphorylating the tyrosine residue, and as a result preventing the proliferation of hematopoietic cells that express BCR-ABL. Therapy with imatinib results in a dramatic reduction of tumor clone cells and the occurrence of blast crisis', through targeted drug treatment which leaves health cells unscathed.
Heart To Heart: Heart Valve Diseases
UCSF's Osher Lifelong Learning Institute presents this series exploring the latest science about the treatment and managment of Cardiovascular disease. Join Jonathan Zaroff, MD, Director Coronary Care Unit, UCSF, Medical Center., for a look at the pathology, diagnosis and treatment of Heart Valve Disease.
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